FRIDAY, July 9 (HealthDay News) -- Researchers report that
they've discovered tiny molecules that appear to forestall cocaine
addiction in rats and may have the same effect in humans.
The findings, reported in the July 8 issue of the journal
Nature, are preliminary, but they "offer promise for the development of a totally new class of anti-addiction medications," said study senior author Paul J. Kenny, an associate professor at Scripps Research Institute in Jupiter, Fla., in a news release from the U.S. National Institute on Drug Abuse (NIDA), which funded the study.
The molecules at issue, known as microRNAs, are a part of RNA
and help the body follow the genetic instructions in DNA.
In the study, researchers gave cocaine to rats and discovered
that it boosted levels of a specific sequence of microRNA in the
brain. The rats disliked cocaine more as the levels went up, but
liked it more as they went down.
"This study enhances our understanding of how brain mechanisms, at their most fundamental levels, may contribute to cocaine addiction vulnerability or resistance to it," Dr. Nora D. Volkow, NIDA director, said in the news release.
The findings may help explain why certain people become addicted
to cocaine -- an estimated 15 percent of those who try it -- while
most do not, the researchers noted.
At the moment, there's no anti-addiction drug to treat cocaine
addicts, said addiction specialist Steven Shoptaw in an interview.
But this research comes with a caveat, he added: cocaine addiction
in rats fails "to fully account for the complexity of cocaine
dependence in humans."
On the other hand, the findings "may be the first steps to
describing the long sought-after 'switch'" that transforms cocaine
use into cocaine addiction, said Shoptaw, a psychologist at the
University of California at Los Angeles.
If the research does result in an anti-addiction drug, it will
still be a challenge to convince people to use it, said addiction
specialist Dr. Adam Bisaga, an associate professor of clinical
psychiatry at Columbia University College of Physicians and
Surgeons in New York City.
"Even if we have an effective medication, it needs to be a medication that patients are willing to take," Bisaga explained. "Some extremely effective treatments, such as Antabuse for alcohol dependence, are underutilized because these medications require a lot of effort on the part of the doctor to work with patients to accept this treatment."
For more about
cocaine, visit the U.S. National Library of Medicine.